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Considering the reduced biosynthetic capacity of erythrocytes, they accumulate oxidative changes along their life span and, therefore, the OS-induced changes in RBCs could be used as useful biomarkers in several pathological and physiological conditions

The same dynamism applies to immune cells, whose own metabolic reprogramming and vulnerability to ferroptosis are dictated by the local nutrient and redox environment shaped by the entire cellular community

Pathophysiology of acute pancreatitis

This pairing is most useful when chronic inflammation is actively blocking repair conditions like IBD flares, post-surgical inflammation, or injuries where swelling persists beyond the normal acute window